BASEBiological Archive
for Science & Education
Search
HomeExploreAcquired Drug resistance
Process

Acquired Drug resistance

Acquired drug resistance

A reduction in drug response that develops as cells or tumors adapt under treatment pressure.

Overview

EXPLORE BY LEVEL

A medicine can slow some cells while other cells survive and adapt. Over time, those surviving cells may make the treatment less effective.

Quick Facts

AT A GLANCE
Explore nextMolecular medicine

Follow the Connections

See how Acquired Drug resistance links to other biological records.

Open network
ConceptResistance To kinase inhibitorscan affectProcessCovalent KRAS inhibitioncan limit
All 2 Structured Connections
Acquired Drug resistance · ProcessCAN AFFECT →Resistance To kinase inhibitors · Concept
Acquired Drug resistance · ProcessCAN LIMIT →Covalent KRAS inhibition · Process

Recommended Reading

Trusted references for learning more about Acquired Drug resistance.

reviewMechanisms of drug resistance in kinasesPubMed · PMID 21235428 articleMEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cellsPubMed · PMID 37336286 articleRAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)PubMed · PMID 22113612
Research Claims

Resistance emerges through evolutionary selection and dynamic network adaptation. Serial molecular profiling, pharmacodynamic measurements, and functional studies help distinguish cause from correlation.