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Concept

Resistance To kinase inhibitors

Resistance to kinase inhibitors

Tumor cells can restore signaling or alter drug binding so a kinase inhibitor loses effect.

Overview

EXPLORE BY LEVEL

A cancer medicine may work at first, but some cells can later find ways around it. They may change the target or turn the growth signal back on another way.

Quick Facts

AT A GLANCE
Explore nextDrug discovery

Follow the Connections

See how Resistance To kinase inhibitors links to other biological records.

Open network
PathwayRAS-RAF-MEK-ERK Signaling (MAPK)can reactivateProcessAcquired Drug resistancecan affect
All 2 Structured Connections
Resistance To kinase inhibitors · ConceptCAN REACTIVATE →RAS-RAF-MEK-ERK Signaling (MAPK) · Pathway
Acquired Drug resistance · ProcessCAN AFFECT →Resistance To kinase inhibitors · Concept

Recommended Reading

Trusted references for learning more about Resistance To kinase inhibitors.

reviewMechanisms of drug resistance in kinasesPubMed · PMID 21235428 articleRAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)PubMed · PMID 22113612
Research Claims

Resistance is an evolving population-level phenotype. Longitudinal genomic and functional evidence can distinguish on-target changes from bypass circuitry and guide rational combination hypotheses.