Process

Protein Folding and Quality Control

Protein Folding and Quality Control

How a protein chain adopts and maintains a functional structure, with cellular systems handling misfolded products.

Overview

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A new protein chain must fold into a useful shape. Cells have helpers that support folding and systems that detect or remove many proteins that do not fold properly.

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Research Claims

Folding landscapes, chaperone cycles, degradation, and stress responses are integrated and compartment-specific. Misfolding can have diverse consequences; it does not automatically imply disease.