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How Statins lower cholesterol

How statins lower cholesterol

Statins inhibit HMG-CoA reductase and can increase hepatic uptake of LDL from the circulation.

Overview

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Statins block a key the liver uses to make cholesterol. The liver then responds by bringing more LDL particles in from the blood.

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ProteinHMG-CoA Reductaseinhibits
All 1 Structured Connections
How Statins lower cholesterol · ProcessINHIBITS →HMG-CoA Reductase · Protein

Recommended Reading

Trusted references for learning more about How Statins lower cholesterol.

pathwayCholesterol biosynthesis (R-HSA-191273)Reactome · Homo sapiens articleEvolocumab and Clinical Outcomes in Patients with Cardiovascular DiseasePubMed · PMID 28304224
Research Claims

Statin responses combine target inhibition with compensatory regulation of cholesterol synthesis and uptake. Magnitude varies by dose, adherence, genotype, baseline physiology, and interacting medicines.