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Protein

HMG-CoA Reductase

HMG-CoA reductase

A rate-controlling enzyme in the mevalonate pathway and the molecular target of statin medicines.

Overview

EXPLORE BY LEVEL

HMG-CoA reductase helps the body make cholesterol. Statin medicines reduce its activity, lowering cholesterol production in the liver.

Quick Facts

AT A GLANCE
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Follow the Connections

See how HMG-CoA Reductase links to other biological records.

Open network
ProcessCholesterol Homeostasisregulated byProcessHow Statins lower cholesterolinhibits
All 2 Structured Connections
Cholesterol Homeostasis · ProcessREGULATED BY →HMG-CoA Reductase · Protein
How Statins lower cholesterol · ProcessINHIBITS →HMG-CoA Reductase · Protein

Recommended Reading

Trusted references for learning more about HMG-CoA Reductase.

pathwayCholesterol biosynthesis (R-HSA-191273)Reactome · Homo sapiens articleEvolocumab and Clinical Outcomes in Patients with Cardiovascular DiseasePubMed · PMID 28304224
Research Claims

HMGCR activity is regulated by sterol-responsive transcription, degradation, phosphorylation, and substrate supply. The clinical effect of statins reflects both hepatic synthesis reduction and altered lipoprotein clearance.