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Protein

β-arrestin

β-arrestin

Adaptor proteins that can reduce GPCR coupling to G proteins and organize receptor trafficking or other signaling events.

Overview

EXPLORE BY LEVEL

After a GPCR has been activated, β-arrestin can help turn down its connection to G proteins and help move the into the cell.

Quick Facts

AT A GLANCE
Explore nextCell signaling

Follow the Connections

See how β-arrestin links to other biological records.

Open network
PathwayGPCR Signalingregulates
All 2 Structured Connections
β-arrestin · ProteinREGULATES →GPCR Signaling · Pathway
β-arrestin · ProteinCAN PROMOTE UNCOUPLING AND INTERNALIZATION IN →GPCR Signaling · Pathway

Recommended Reading

Trusted references for learning more about β-arrestin.

pathwaySignaling by GPCR (R-HSA-372790)Reactome · Homo sapiens textbookGeneral Principles of Cell CommunicationMolecular Biology of the Cell · NCBI Bookshelf reviewG protein-coupled receptor kinases and arrestinsPharmacological Reviews · PMC4779377
Research Claims

Arrestin recruitment, receptor internalization, and arrestin-associated signaling depend on receptor phosphorylation patterns, ligand, cell type, and experimental readout.