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GPCR Signaling

GPCR signaling

How G-protein-coupled receptors convert outside signals into intracellular changes.

Overview

EXPLORE BY LEVEL

A GPCR is a cell-surface . When a signal binds, the activates helper proteins inside the cell and starts a response.

Quick Facts

AT A GLANCE
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Follow the Connections

See how GPCR Signaling links to other biological records.

Open network
ConceptSecond Messengersrelay signal fromConceptGPCR Agonists and antagonistsmodulateProteinβ-arrestinregulatesMoleculeCyclic AMPamplifies
All 7 Structured Connections
Second Messengers · ConceptRELAY SIGNAL FROM →GPCR Signaling · Pathway
GPCR Agonists and antagonists · ConceptMODULATE →GPCR Signaling · Pathway
β-arrestin · ProteinREGULATES →GPCR Signaling · Pathway
Cyclic AMP · MoleculeAMPLIFIES →GPCR Signaling · Pathway
Gs–cAMP–PKA Signaling · PathwayIS A BRANCH OF →GPCR Signaling · Pathway
RGS Proteins · ProteinREGULATES SELECTED G ALPHA SWITCHES IN →GPCR Signaling · Pathway
β-arrestin · ProteinCAN PROMOTE UNCOUPLING AND INTERNALIZATION IN →GPCR Signaling · Pathway

Recommended Reading

Trusted references for learning more about GPCR Signaling.

pathwaySignaling by GPCR (R-HSA-372790)Reactome · Homo sapiens textbookGeneral Principles of Cell CommunicationMolecular Biology of the Cell · NCBI Bookshelf pathwayG alpha (s) signalling events (R-HSA-418555)Reactome · Homo sapiens articleRapid GTP binding and hydrolysis by G(q) promoted by receptor and GTPase-activating proteinsPNAS · PMID 10449728
Show 1 more sources
G protein-coupled receptor kinases and arrestinsPharmacological Reviews · PMC4779377 · review
Research Claims

GPCR output depends on receptor subtype, ligand, G-protein family, effector expression, and desensitization. One receptor can couple to more than one downstream pathway.