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Protein

PTEN

phosphatase and tensin homolog

A lipid phosphatase that removes a phosphate from PIP3, opposing PI3K and reducing a signal that helps recruit AKT to the membrane.

Overview

EXPLORE BY LEVEL

PTEN is a protein that helps pass or control signals inside cells. A lipid phosphatase that removes a phosphate from PIP3, opposing PI3K and reducing a signal that helps recruit AKT to the membrane.

Quick Facts

AT A GLANCE
Encoded byPTEN
Rolepi3k akt mtor

Follow the Connections

See how PTEN links to other biological records.

Open network
GenePTENencodesPathwayPI3K-AKT-mTOR Signalingparticipates inMoleculePIP3dephosphorylates
All 3 Structured Connections
PTEN · GeneENCODES →PTEN · Protein
PTEN · ProteinPARTICIPATES IN →PI3K-AKT-mTOR Signaling · Pathway
PTEN · ProteinDEPHOSPHORYLATES →PIP3 · Molecule

Recommended Reading

Trusted references for learning more about PTEN.

pathwayPIP3 activates AKT signaling (R-HSA-1257604)Reactome · Homo sapiens databasePTEN (5728)NCBI Gene
Research Claims

A lipid phosphatase that removes a phosphate from PIP3, opposing PI3K and reducing a signal that helps recruit AKT to the membrane.