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Molecule

PIP3

Phosphatidylinositol (3,4,5)-trisphosphate

A membrane phospholipid signal made by PI3K from PIP2. PIP3 helps recruit AKT and other proteins to the cell membrane.

Overview

EXPLORE BY LEVEL

PIP3 is a small fat-like signal in the cell membrane. PI3K makes it, and it helps bring proteins such as AKT to the right place to receive a signal.

Quick Facts

AT A GLANCE
Made byClass I PI3K
Removed byPTEN

Follow the Connections

See how PIP3 links to other biological records.

Open network
Molecular complexClass IA PI3KproducesProteinPTENdephosphorylatesProteinAKT1recruitsProteinPDK1 (PDPK1)recruits
All 4 Structured Connections
Class IA PI3K · Molecular complexPRODUCES →PIP3 · Molecule
PTEN · ProteinDEPHOSPHORYLATES →PIP3 · Molecule
PIP3 · MoleculeRECRUITS →AKT1 · Protein
PIP3 · MoleculeRECRUITS →PDK1 (PDPK1) · Protein

Recommended Reading

Trusted references for learning more about PIP3.

pathwayPIP3 activates AKT signaling (R-HSA-1257604)Reactome · Homo sapiens
Research Claims

PI3K generates PIP3 from PIP2; PIP3 recruits AKT, while PTEN opposes the signal by dephosphorylating PIP3.