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RGS Proteins

RGS Proteins

Regulators of G-protein signaling that accelerate GTP hydrolysis by selected heterotrimeric Gα subunits.

Overview

EXPLORE BY LEVEL

Some helper proteins speed up the G-protein switch returning from GTP to GDP. This can shorten signals, but different helpers act on different G-protein types.

Quick Facts

AT A GLANCE
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Follow the Connections

See how RGS Proteins links to other biological records.

Open network
PathwayGPCR Signalingregulates selected g alpha switches in
All 1 Structured Connections
RGS Proteins · ProteinREGULATES SELECTED G ALPHA SWITCHES IN →GPCR Signaling · Pathway

Recommended Reading

Trusted references for learning more about RGS Proteins.

pathwaySignaling by GPCR (R-HSA-372790)Reactome · Homo sapiens articleRapid GTP binding and hydrolysis by G(q) promoted by receptor and GTPase-activating proteinsPNAS · PMID 10449728
Research Claims

RGS family members differ in Gα selectivity, localization, expression, and regulatory interactions. The cited experimental example examines Gαq; extrapolation to Gαs requires subtype-specific evidence.