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siRNA Therapeutics

siRNA therapeutics

Short double-stranded RNAs that guide cellular RNA-interference machinery to a complementary target RNA.

Overview

EXPLORE BY LEVEL

An siRNA carries a sequence that matches a chosen RNA message. It guides the cell's own RNA-silencing machinery to reduce that message.

Quick Facts

AT A GLANCE
Explore nextRNA therapeutics

Follow the Connections

See how siRNA Therapeutics links to other biological records.

Open network
ProcessRNA InterferenceusesDrugInclisiran And PCSK9 RNA interferenceis aMolecular complexRNA-induced Silencing complexcan use
All 3 Structured Connections
siRNA Therapeutics · TherapyUSES →RNA Interference · Process
Inclisiran And PCSK9 RNA interference · DrugIS A →siRNA Therapeutics · Therapy
siRNA Therapeutics · TherapyCAN USE →RNA-induced Silencing complex · Molecular complex

Recommended Reading

Trusted references for learning more about siRNA Therapeutics.

reviewMechanisms and strategies for effective delivery of antisense and siRNA oligonucleotidesPubMed Central reviewCurrent Challenges in Delivery and Cytosolic Translocation of Therapeutic RNAsPubMed Central articleInclisiran in Patients at High Cardiovascular Risk with Elevated LDL CholesterolPubMed · PMID 28306389 articleRNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machineryNucleic Acids Research · PMID 26843429
Research Claims

Therapeutic siRNA performance reflects guide selection, strand loading, target accessibility, off-target recognition, conjugate or carrier design, tissue uptake, and endosomal escape.