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Molecular complex

RNA-induced Silencing complex

RNA-induced silencing complex

A protein complex that uses a guide RNA to recognize and regulate complementary target RNAs.

Overview

EXPLORE BY LEVEL

RISC is a protein team that carries a guide RNA. The guide helps the team find a matching RNA message and reduce its effect.

Quick Facts

AT A GLANCE
Explore nextRNA therapeutics

Follow the Connections

See how RNA-induced Silencing complex links to other biological records.

Open network
ProcessRNA InterferenceusesProteinAGO2contains catalytic componentMoleculeMessenger RNA (mRNA)can guide cleavage ofTherapysiRNA Therapeuticscan use
All 5 Structured Connections
RNA Interference · ProcessUSES →RNA-induced Silencing complex · Molecular complex
RNA-induced Silencing complex · Molecular complexCONTAINS CATALYTIC COMPONENT →AGO2 · Protein
RNA-induced Silencing complex · Molecular complexCAN GUIDE CLEAVAGE OF →Messenger RNA (mRNA) · Molecule
siRNA Therapeutics · TherapyCAN USE →RNA-induced Silencing complex · Molecular complex
AGO2 · ProteinPARTICIPATES IN →RNA-induced Silencing complex · Molecular complex

Recommended Reading

Trusted references for learning more about RNA-induced Silencing complex.

reviewMechanisms and strategies for effective delivery of antisense and siRNA oligonucleotidesPubMed Central reviewCurrent Challenges in Delivery and Cytosolic Translocation of Therapeutic RNAsPubMed Central articleRNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machineryNucleic Acids Research · PMID 26843429 databaseAGO2 (27161)NCBI Gene
Research Claims

RISC assembly, guide-strand selection, target pairing, and turnover are regulated processes. Therapeutic activity requires enough active guide-loaded complex in the correct intracellular compartment.