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Molecular complex

PCSK9–LDLR Complex

Proprotein convertase subtilisin/kexin type 9 bound to LDL receptor

A receptor–ligand complex formed when PCSK9 binds LDLR. This interaction can change receptor trafficking and favor lysosomal degradation rather than recycling.

Overview

EXPLORE BY LEVEL

PCSK9–LDLR Complex is a team of proteins that works together as one signaling unit. A –ligand complex formed when PCSK9 binds LDLR. This interaction can change trafficking and favor lysosomal degradation rather than recycling.

Quick Facts

AT A GLANCE
Molecular formMulti-protein complex
Key subunitsPCSK9, LDL receptor (LDLR)

Follow the Connections

See how PCSK9–LDLR Complex links to other biological records.

Open network
ProteinPCSK9part ofProteinLDL Receptorpart of
All 2 Structured Connections
PCSK9 · ProteinPART OF →PCSK9–LDLR Complex · Molecular complex
LDL Receptor · ProteinPART OF →PCSK9–LDLR Complex · Molecular complex

Recommended Reading

Trusted references for learning more about PCSK9–LDLR Complex.

pathwayPCSK9 binds LDLR (R-HSA-6784734)Reactome · Homo sapiens pathwayPCSK9:LDLR degradation (R-HSA-6784738)Reactome · Homo sapiens
Research Claims

A receptor–ligand complex formed when PCSK9 binds LDLR. This interaction can change receptor trafficking and favor lysosomal degradation rather than recycling.