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Protein

PCSK9

PCSK9

A protein that can promote LDL-receptor degradation and thereby influence LDL cholesterol levels.

Overview

EXPLORE BY LEVEL

PCSK9 can attach to LDL receptors and send them toward breakdown inside the cell. With fewer receptors available, less LDL may be cleared from the blood.

Quick Facts

AT A GLANCE
Explore nextMolecular medicine

Follow the Connections

See how PCSK9 links to other biological records.

Open network
ProteinLDL Receptortargeted for degradation byDrugInclisiran And PCSK9 RNA interferencereduces mrna forMolecular complexPCSK9–LDLR Complexpart ofPathwayLDL Clearance and PCSK9can reduce
All 8 Structured Connections
LDL Receptor · ProteinTARGETED FOR DEGRADATION BY →PCSK9 · Protein
Inclisiran And PCSK9 RNA interference · DrugREDUCES MRNA FOR →PCSK9 · Protein
PCSK9 · ProteinBINDS →LDL Receptor · Protein
PCSK9 · ProteinPART OF →PCSK9–LDLR Complex · Molecular complex
PCSK9 · ProteinCAN PROMOTE LYSOSOMAL DEGRADATION OF →LDL Receptor · Protein
PCSK9 · ProteinCAN REDUCE →LDL Clearance and PCSK9 · Pathway
Therapeutic Antibodies · TherapyCAN NEUTRALIZE →PCSK9 · Protein
Inclisiran And PCSK9 RNA interference · DrugREDUCES MRNA FOR →PCSK9 · Protein

Recommended Reading

Trusted references for learning more about PCSK9.

articleEvolocumab and Clinical Outcomes in Patients with Cardiovascular DiseasePubMed · PMID 28304224 articleInclisiran in Patients at High Cardiovascular Risk with Elevated LDL CholesterolPubMed · PMID 28306389 pathwayPCSK9 binds LDLR (R-HSA-6784734)Reactome · Homo sapiens pathwayPCSK9:LDLR degradation (R-HSA-6784738)Reactome · Homo sapiens
Show 1 more sources
LDL clearance (R-HSA-8964038)Reactome · Homo sapiens · pathway
Research Claims

PCSK9 effects depend on receptor binding, trafficking, tissue production, and systemic clearance. Antibody and siRNA modalities act at different points and should not be treated as interchangeable mechanisms.