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Protein

LDL Receptor

LDL receptor

A cell-surface receptor that binds LDL particles and helps cells, especially liver cells, remove them from circulation.

Overview

EXPLORE BY LEVEL

The LDL acts like a catcher on the surface of a cell. It binds LDL particles and brings them inside, helping clear LDL from the blood.

Quick Facts

AT A GLANCE
Explore nextMolecular medicine

Follow the Connections

See how LDL Receptor links to other biological records.

Open network
ProteinPCSK9targeted for degradation byMolecular complexPCSK9–LDLR Complexpart ofMolecular complexLDL Particlebinds and internalizesPathwayLDL Clearance and PCSK9uses
All 6 Structured Connections
LDL Receptor · ProteinTARGETED FOR DEGRADATION BY →PCSK9 · Protein
PCSK9 · ProteinBINDS →LDL Receptor · Protein
LDL Receptor · ProteinPART OF →PCSK9–LDLR Complex · Molecular complex
PCSK9 · ProteinCAN PROMOTE LYSOSOMAL DEGRADATION OF →LDL Receptor · Protein
LDL Receptor · ProteinBINDS AND INTERNALIZES →LDL Particle · Molecular complex
LDL Clearance and PCSK9 · PathwayUSES →LDL Receptor · Protein

Recommended Reading

Trusted references for learning more about LDL Receptor.

articleEvolocumab and Clinical Outcomes in Patients with Cardiovascular DiseasePubMed · PMID 28304224 articleInclisiran in Patients at High Cardiovascular Risk with Elevated LDL CholesterolPubMed · PMID 28306389 pathwayCholesterol biosynthesis (R-HSA-191273)Reactome · Homo sapiens pathwayPCSK9 binds LDLR (R-HSA-6784734)Reactome · Homo sapiens
Show 2 more sources
PCSK9:LDLR degradation (R-HSA-6784738)Reactome · Homo sapiens · pathwayLDL clearance (R-HSA-8964038)Reactome · Homo sapiens · pathway
Research Claims

LDLR abundance is regulated transcriptionally and post-translationally. PCSK9 can route LDLR toward lysosomal degradation, while therapies that reduce PCSK9 activity can preserve receptor availability.