Conversion of oxaloacetate to phosphoenolpyruvate
PEP carboxykinase uses GTP to decarboxylate and phosphorylate oxaloacetate.
Gluconeogenesis · irreversibleBUILD UP YOUR UNDERSTANDING
Learn about Carbon dioxide
A gas whose carbon atoms can be incorporated into organic molecules during photosynthesis. is a small molecule that cells make, use, or change in connected metabolic reactions.
Start here for the main idea. Choose Learn for reactions and connections.
QUICK FACTS
At a glance
Carbon backbone 1 CThis carbon count is shown where it is defined for the molecule.
FOLLOW THE BIOLOGY
17 linksConnected records
Produced inGluconeogenesisProduced inPentose phosphate pathwayProduced inPyruvate oxidationProduced inCitric acid cycleProduced inFatty acid synthesisProduced inCholesterol biosynthesisProduced inBranched-chain amino acid catabolismProduced inPyrimidine nucleotide synthesis
Show 9 more connections
Handled byPhosphoenolpyruvate carboxykinase (cytosolic)Handled by6-Phosphogluconate dehydrogenaseHandled byPyruvate dehydrogenase complexHandled byNAD-dependent isocitrate dehydrogenaseHandled by2-Oxoglutarate dehydrogenase complexHandled byFatty acid synthaseHandled byMevalonate diphosphate decarboxylaseHandled byBranched-chain alpha-keto-acid dehydrogenase complexHandled byOMP decarboxylase
STRUCTURED REACTIONS
Open metabolism map Where it appears
Oxidative decarboxylation
6-Phosphogluconate dehydrogenase releases CO2 and makes a second NADPH.
Pentose phosphate pathway · irreversiblePyruvate dehydrogenase reaction
The multienzyme complex oxidizes pyruvate, releases CO2, and forms acetyl-CoA and NADH.
Pyruvate oxidation · irreversibleFirst oxidative decarboxylation
NAD-dependent isocitrate dehydrogenase produces 2-oxoglutarate, CO2, and NADH.
Citric acid cycle · irreversibleSecond oxidative decarboxylation
The 2-oxoglutarate dehydrogenase complex forms succinyl-CoA, CO2, and NADH.
Citric acid cycle · irreversibleMalonyl condensation
Decarboxylative condensation adds two carbons from malonyl-CoA.
Fatty acid synthesis · irreversibleShow 3 more reaction records
Isopentenyl diphosphate formation
Mevalonate diphosphate decarboxylase produces the five-carbon isoprene unit IPP.
Cholesterol biosynthesis · irreversibleOxidative decarboxylation
The BCKDH complex converts the branched-chain keto acids to acyl-CoA products and NADH.
Branched-chain amino acid catabolism · irreversibleUMP formation
OMP decarboxylase produces UMP, the first pyrimidine nucleotide in the pathway.
Pyrimidine nucleotide synthesis · irreversible