BASEBiological Archive
for Science & Education
Search
HomeExploreInsulin Signaling
Pathway

Insulin Signaling

Insulin signaling

How insulin receptor signaling coordinates glucose uptake and nutrient storage.

Overview

EXPLORE BY LEVEL

Insulin is a hormone released after a meal. It binds to a on certain cells and helps move transporters to the cell surface, so those cells can take up .

Quick Facts

AT A GLANCE
Explore nextCell signaling

Follow the Connections

See how Insulin Signaling links to other biological records.

Open network
PathwayGlycolysisregulatesProcessMembrane TransportpromotesCell componentPlasma Membranepromotes glut4 traffic toPathwayRAS-RAF-MEK-ERK Signaling (MAPK)crosstalks with
All 13 Structured Connections
Insulin Signaling · PathwayREGULATES →Glycolysis · Pathway
Insulin Signaling · PathwayPROMOTES →Membrane Transport · Process
Insulin Signaling · PathwayPROMOTES GLUT4 TRAFFIC TO →Plasma Membrane · Cell component
Insulin Signaling · PathwayCROSSTALKS WITH →RAS-RAF-MEK-ERK Signaling (MAPK) · Pathway
GLUT4 Glucose uptake · ProcessPARTICIPATES IN →Insulin Signaling · Pathway
Insulin Receptor · ProteinACTIVATES →Insulin Signaling · Pathway
Insulin Signaling · PathwayPROMOTES →GLUT4 Glucose uptake · Process
Fed And fasting states · ConceptREGULATES →Insulin Signaling · Pathway
AKT2 · ProteinPARTICIPATES IN →Insulin Signaling · Pathway
TBC1D4 (AS160) · ProteinPARTICIPATES IN →Insulin Signaling · Pathway
GSK3β · ProteinPARTICIPATES IN →Insulin Signaling · Pathway
FOXO1 · ProteinPARTICIPATES IN →Insulin Signaling · Pathway
Insulin Signaling · PathwayREGULATES →Homeostasis · Process

Recommended Reading

Trusted references for learning more about Insulin Signaling.

pathwaySignaling by insulin receptor (R-HSA-74752)Reactome · Homo sapiens pathwayTranslocation of SLC2A4 (GLUT4) to the plasma membraneReactome · Homo sapiens pathwayGlycolysis (R-HSA-70171)Reactome · Homo sapiens reviewBiochemistry, Insulin Metabolic EffectsNCBI Bookshelf
Show 2 more sources
Insulin action at a molecular level – 100 years of progressKahn et al. · Molecular Metabolism · 2021 · reviewRoles of TBC1D1 and TBC1D4 in insulin- and exercise-stimulated glucose transport of skeletal muscleCartee · Diabetologia · 2015 · review
Research Claims

Reactome's human insulin-receptor network includes IRS signaling, PI3K and RAS/MAPK branches, and downstream GLUT4 translocation. The pathway is tissue-specific and should not be treated as a single linear chain.