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LDL Clearance and PCSK9

Human LDL receptor-mediated clearance and PCSK9-dependent receptor degradation

An LDLR trafficking route that helps clear LDL particles from circulation and is regulated by PCSK9.

REACTOME IDENTIFIERR-HSA-8964038View source record ↗

Overview

EXPLORE BY LEVEL

Liver cells use LDL receptors to capture LDL particles. The receptors can be reused, but PCSK9 can send some to be broken down. PCSK9-blocking medicines can help preserve receptors through different mechanisms.

Quick Facts

AT A GLANCE
Core RouteLDL binds LDLR → uptake → receptor recycling or degradation
PCSK9 EffectPCSK9 can favor lysosomal LDLR degradation over recycling
ScopeSelected human hepatic clearance mechanism; not a patient-specific treatment prediction

Follow the Connections

See how LDL Clearance and PCSK9 links to other biological records.

Open network
ProteinLDL ReceptorusesMolecular complexLDL ParticleclearsProteinPCSK9can reduce
All 3 Structured Connections
LDL Clearance and PCSK9 · PathwayUSES →LDL Receptor · Protein
LDL Clearance and PCSK9 · PathwayCLEARS →LDL Particle · Molecular complex
PCSK9 · ProteinCAN REDUCE →LDL Clearance and PCSK9 · Pathway

Recommended Reading

Trusted references for learning more about LDL Clearance and PCSK9.

pathwayPCSK9 binds LDLR (R-HSA-6784734)Reactome · Homo sapiens pathwayPCSK9:LDLR degradation (R-HSA-6784738)Reactome · Homo sapiens pathwayLDL clearance (R-HSA-8964038)Reactome · Homo sapiens articleEvolocumab and Clinical Outcomes in Patients with Cardiovascular DiseasePubMed · PMID 28304224
Show 1 more sources
Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL CholesterolPubMed · PMID 28306389 · article
Research Claims

The map captures receptor availability as one determinant of plasma LDL clearance. It abstracts from LDL production, apoB secretion, receptor expression control, tissue distribution, and patient-level pharmacology. Antibody and siRNA effects should be distinguished by target compartment and pharmacodynamic evidence.