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Protein Phosphorylation

Protein phosphorylation

A reversible chemical modification that can change a protein's activity or interactions.

Overview

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Adding a phosphate group can change a protein's shape or how it interacts with other molecules. Cells use this change to control many processes.

Quick Facts

AT A GLANCE
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Follow the Connections

See how Protein Phosphorylation links to other biological records.

Open network
ConceptProtein Kinasesadds phosphate inConceptProtein Phosphatasesremoves phosphate inPathwayRAS-RAF-MEK-ERK Signaling (MAPK)regulates
All 3 Structured Connections
Protein Kinases · ConceptADDS PHOSPHATE IN →Protein Phosphorylation · Process
Protein Phosphatases · ConceptREMOVES PHOSPHATE IN →Protein Phosphorylation · Process
Protein Phosphorylation · ProcessREGULATES →RAS-RAF-MEK-ERK Signaling (MAPK) · Pathway

Recommended Reading

Trusted references for learning more about Protein Phosphorylation.

textbookGeneral Principles of Cell CommunicationMolecular Biology of the Cell · NCBI Bookshelf textbookThe Cell Cycle and Programmed Cell DeathMolecular Biology of the Cell · NCBI Bookshelf pathwayRAF/MAP kinase cascade (R-HSA-5673001)Reactome · Homo sapiens
Research Claims

Phosphorylation effects are residue- and context-specific, with combinatorial and temporal regulation. Detecting a phosphosite does not alone establish its functional consequence.