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Protein

ERK1 (MAPK3)

mitogen-activated protein kinase 3

A MAP kinase activated by MEK1 or MEK2. ERK1 can phosphorylate many targets; its effects depend on the cell and signal context.

Overview

EXPLORE BY LEVEL

ERK1 (MAPK3) is a protein that helps pass or control signals inside cells. A MAP kinase activated by MEK1 or MEK2. ERK1 can phosphorylate many targets; its effects depend on the cell and signal context.

Quick Facts

AT A GLANCE
Encoded byMAPK3
Rolemapk signaling

Follow the Connections

See how ERK1 (MAPK3) links to other biological records.

Open network
GeneMAPK3encodesPathwayRAS-RAF-MEK-ERK Signaling (MAPK)participates inProteinMEK1 (MAP2K1)phosphorylatesProteinMEK2 (MAP2K2)phosphorylates
All 5 Structured Connections
MAPK3 · GeneENCODES →ERK1 (MAPK3) · Protein
ERK1 (MAPK3) · ProteinPARTICIPATES IN →RAS-RAF-MEK-ERK Signaling (MAPK) · Pathway
MEK1 (MAP2K1) · ProteinPHOSPHORYLATES →ERK1 (MAPK3) · Protein
MEK2 (MAP2K2) · ProteinPHOSPHORYLATES →ERK1 (MAPK3) · Protein
DUSP6 · ProteinDEPHOSPHORYLATES →ERK1 (MAPK3) · Protein

Recommended Reading

Trusted references for learning more about ERK1 (MAPK3).

pathwayRAF/MAP kinase cascade (R-HSA-5673001)Reactome · Homo sapiens databaseMAPK3 (5595)NCBI Gene
Research Claims

A MAP kinase activated by MEK1 or MEK2. ERK1 can phosphorylate many targets; its effects depend on the cell and signal context.