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Protein

MEK1 (MAP2K1)

mitogen-activated protein kinase kinase 1

A dual-specificity kinase in the MAPK cascade. MEK1 phosphorylates ERK proteins downstream of RAF-family kinases.

Overview

EXPLORE BY LEVEL

MEK1 (MAP2K1) is a protein that helps pass or control signals inside cells. A dual-specificity kinase in the MAPK cascade. MEK1 phosphorylates ERK proteins downstream of RAF-family kinases.

Quick Facts

AT A GLANCE
Encoded byMAP2K1
Rolemapk signaling

Follow the Connections

See how MEK1 (MAP2K1) links to other biological records.

Open network
GeneMAP2K1encodesPathwayRAS-RAF-MEK-ERK Signaling (MAPK)participates inProteinBRAFphosphorylatesProteinRAF1 (C-RAF)phosphorylates
All 6 Structured Connections
MAP2K1 · GeneENCODES →MEK1 (MAP2K1) · Protein
MEK1 (MAP2K1) · ProteinPARTICIPATES IN →RAS-RAF-MEK-ERK Signaling (MAPK) · Pathway
BRAF · ProteinPHOSPHORYLATES →MEK1 (MAP2K1) · Protein
RAF1 (C-RAF) · ProteinPHOSPHORYLATES →MEK1 (MAP2K1) · Protein
MEK1 (MAP2K1) · ProteinPHOSPHORYLATES →ERK1 (MAPK3) · Protein
MEK1 (MAP2K1) · ProteinPHOSPHORYLATES →ERK2 (MAPK1) · Protein

Recommended Reading

Trusted references for learning more about MEK1 (MAP2K1).

pathwayRAF/MAP kinase cascade (R-HSA-5673001)Reactome · Homo sapiens databaseMAP2K1 (5604)NCBI Gene
Research Claims

A dual-specificity kinase in the MAPK cascade. MEK1 phosphorylates ERK proteins downstream of RAF-family kinases.