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BRAF V600E and MAPK signaling

BRAF V600E and MAPK signaling

A recurrent BRAF variant that can drive MAPK-pathway signaling and create a context-dependent drug target.

Overview

EXPLORE BY LEVEL

BRAF is part of a cell-growth signaling chain. The V600E change can leave this signal unusually active, which can help some tumors grow.

Quick Facts

AT A GLANCE
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Follow the Connections

See how BRAF V600E and MAPK signaling links to other biological records.

Open network
PathwayRAS-RAF-MEK-ERK Signaling (MAPK)activatesProteinBRAFvariant of
All 2 Structured Connections
BRAF V600E and MAPK signaling · VariantACTIVATES →RAS-RAF-MEK-ERK Signaling (MAPK) · Pathway
BRAF V600E and MAPK signaling · VariantVARIANT OF →BRAF · Protein

Recommended Reading

Trusted references for learning more about BRAF V600E and MAPK signaling.

articleRAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)PubMed · PMID 22113612 pathwayRAF/MAP kinase cascade (R-HSA-5673001)Reactome · Homo sapiens
Research Claims

BRAF V600E is a context-dependent driver. Inhibitor response differs across tumor lineages, and adaptive signaling can restore ERK output through receptor feedback, RAF dimerization, or other network changes.