BASEBiological Archive
for Science & Education
Search
HomeExploreBRAF
Protein

BRAF

B-Raf proto-oncogene, serine/threonine kinase

A RAF-family kinase that relays signals from RAS toward MEK1 and MEK2. Its activity depends on cellular context and regulatory interactions.

Overview

EXPLORE BY LEVEL

BRAF is a protein that helps pass or control signals inside cells. A RAF-family kinase that relays signals from RAS toward MEK1 and MEK2. Its activity depends on cellular context and regulatory interactions.

Quick Facts

AT A GLANCE
Encoded byBRAF
Rolemapk signaling

Follow the Connections

See how BRAF links to other biological records.

Open network
GeneBRAFencodesPathwayRAS-RAF-MEK-ERK Signaling (MAPK)participates inProteinKRASactivatesProteinMEK1 (MAP2K1)phosphorylates
All 6 Structured Connections
BRAF · GeneENCODES →BRAF · Protein
BRAF · ProteinPARTICIPATES IN →RAS-RAF-MEK-ERK Signaling (MAPK) · Pathway
KRAS · ProteinACTIVATES →BRAF · Protein
BRAF · ProteinPHOSPHORYLATES →MEK1 (MAP2K1) · Protein
BRAF · ProteinPHOSPHORYLATES →MEK2 (MAP2K2) · Protein
BRAF V600E and MAPK signaling · VariantVARIANT OF →BRAF · Protein

Recommended Reading

Trusted references for learning more about BRAF.

pathwayRAF/MAP kinase cascade (R-HSA-5673001)Reactome · Homo sapiens databaseBRAF (673)NCBI Gene articleRAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)PubMed · PMID 22113612
Research Claims

A RAF-family kinase that relays signals from RAS toward MEK1 and MEK2. Its activity depends on cellular context and regulatory interactions.