Pyruvate dehydrogenase reaction
The multienzyme complex oxidizes pyruvate, releases CO2, and forms acetyl-CoA and NADH.
Pyruvate oxidation · irreversibleBUILD UP YOUR UNDERSTANDING
Learn about Coenzyme A
Coenzyme A is a small molecule that cells make, use, or change in connected metabolic reactions.
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QUICK FACTS
At a glance
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16 linksConnected records
Used inPyruvate oxidationUsed and produced inCitric acid cycleUsed inFatty acid β-oxidationUsed inFatty acid synthesisProduced inCholesterol biosynthesisUsed inBranched-chain amino acid catabolismHandled byPyruvate dehydrogenase complexHandled byCitrate synthase
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Handled by2-Oxoglutarate dehydrogenase complexHandled bySuccinyl-CoA synthetaseHandled byAcetyl-CoA acyltransferase 2Handled byATP-citrate lyaseHandled byFatty acid synthaseHandled byHMG-CoA synthase (cytosolic)Handled byHMG-CoA reductaseHandled byBranched-chain alpha-keto-acid dehydrogenase complex
STRUCTURED REACTIONS
Open metabolism map Where it appears
Citrate formation
Citrate synthase condenses acetyl-CoA and oxaloacetate.
Citric acid cycle · irreversibleSecond oxidative decarboxylation
The 2-oxoglutarate dehydrogenase complex forms succinyl-CoA, CO2, and NADH.
Citric acid cycle · irreversibleGTP formation
Succinyl-CoA synthetase couples thioester cleavage to GTP formation.
Citric acid cycle · irreversibleThiolytic cleavage
Thiolase releases one acetyl-CoA and a fatty acyl-CoA shortened by two carbons.
Fatty acid β-oxidation · irreversibleCytosolic acetyl-CoA supply
ATP-citrate lyase provides cytosolic acetyl-CoA from exported citrate.
Fatty acid synthesis · irreversibleShow 6 more reaction records
Malonyl condensation
Decarboxylative condensation adds two carbons from malonyl-CoA.
Fatty acid synthesis · irreversibleAcetoacetyl-CoA formation
Thiolase condenses two acetyl-CoA molecules to form acetoacetyl-CoA.
Cholesterol biosynthesis · irreversibleHMG-CoA formation
Cytosolic HMG-CoA synthase adds a third acetyl unit to acetoacetyl-CoA.
Cholesterol biosynthesis · irreversibleMevalonate formation
HMG-CoA reductase uses NADPH to produce mevalonate.
Cholesterol biosynthesis · irreversibleOxidative decarboxylation
The BCKDH complex converts the branched-chain keto acids to acyl-CoA products and NADH.
Branched-chain amino acid catabolism · irreversibleIsoleucine carbon to acetyl-CoA and propionyl-CoA
The isoleucine branch yields both acetyl-CoA and propionyl-CoA.
Branched-chain amino acid catabolism · irreversible