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Molecular complex

Class IA PI3K

Class IA phosphoinositide 3-kinase heterodimer

A regulatory p85 subunit and catalytic p110 subunit form a lipid kinase complex. When activated, it can convert PIP2 to PIP3, helping recruit AKT and other signaling proteins to the membrane.

Overview

EXPLORE BY LEVEL

Class IA PI3K is a team of proteins that works together as one signaling unit. A regulatory p85 subunit and catalytic p110 subunit form a lipid kinase complex. When activated, it can convert PIP2 to PIP3, helping recruit AKT and other signaling proteins to the membrane.

Quick Facts

AT A GLANCE
Molecular formMulti-protein complex
Key subunitsp110α (PIK3CA), p85α (PIK3R1)

Follow the Connections

See how Class IA PI3K links to other biological records.

Open network
Proteinp110α (PIK3CA)subunit ofProteinp85α (PIK3R1)subunit ofProteinKRASbindsMoleculePIP3produces
All 4 Structured Connections
p110α (PIK3CA) · ProteinSUBUNIT OF →Class IA PI3K · Molecular complex
p85α (PIK3R1) · ProteinSUBUNIT OF →Class IA PI3K · Molecular complex
KRAS · ProteinBINDS →Class IA PI3K · Molecular complex
Class IA PI3K · Molecular complexPRODUCES →PIP3 · Molecule

Recommended Reading

Trusted references for learning more about Class IA PI3K.

pathwayPIP3 activates AKT signaling (R-HSA-1257604)Reactome · Homo sapiens reviewTargeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapyMolecular Biomedicine · 2022 pathwayMTOR signalling (R-HSA-165159)Reactome · Homo sapiens pathwayRAF/MAP kinase cascade (R-HSA-5673001)Reactome · Homo sapiens
Research Claims

A regulatory p85 subunit and catalytic p110 subunit form a lipid kinase complex. When activated, it can convert PIP2 to PIP3, helping recruit AKT and other signaling proteins to the membrane.