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Protein

KRAS

KRAS proto-oncogene, GTPase

A molecular switch that cycles between GDP-bound and GTP-bound states. Active KRAS can recruit RAF and engage other effectors, including PI3K.

Overview

EXPLORE BY LEVEL

KRAS is a protein that helps pass or control signals inside cells. A molecular switch that cycles between GDP-bound and GTP-bound states. Active KRAS can recruit RAF and engage other effectors, including PI3K.

Quick Facts

AT A GLANCE
Encoded byKRAS
Rolemapk signaling; pi3k akt mtor

Follow the Connections

See how KRAS links to other biological records.

Open network
GeneKRASencodesPathwayRAS-RAF-MEK-ERK Signaling (MAPK)participates inPathwayPI3K-AKT-mTOR Signalingparticipates inProteinSOS1activates
All 9 Structured Connections
KRAS · GeneENCODES →KRAS · Protein
KRAS · ProteinPARTICIPATES IN →RAS-RAF-MEK-ERK Signaling (MAPK) · Pathway
KRAS · ProteinPARTICIPATES IN →PI3K-AKT-mTOR Signaling · Pathway
SOS1 · ProteinACTIVATES →KRAS · Protein
KRAS · ProteinACTIVATES →BRAF · Protein
KRAS · ProteinACTIVATES →RAF1 (C-RAF) · Protein
Neurofibromin (NF1) · ProteinINACTIVATES →KRAS · Protein
KRAS · ProteinBINDS →Class IA PI3K · Molecular complex
KRAS G12C · VariantVARIANT OF →KRAS · Protein

Recommended Reading

Trusted references for learning more about KRAS.

pathwayRAF/MAP kinase cascade (R-HSA-5673001)Reactome · Homo sapiens pathwayPIP3 activates AKT signaling (R-HSA-1257604)Reactome · Homo sapiens databaseKRAS (3845)NCBI Gene reviewTargeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRASPubMed · PMID 37221195
Research Claims

A molecular switch that cycles between GDP-bound and GTP-bound states. Active KRAS can recruit RAF and engage other effectors, including PI3K.