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Molecular complex

TSC1–TSC2 Complex

Tuberous sclerosis protein complex

TSC1 and TSC2 form a regulatory complex that acts as a GTPase-activating protein for RHEB. This helps restrain RHEB-driven mTORC1 activity.

Overview

EXPLORE BY LEVEL

TSC1–TSC2 Complex is a team of proteins that works together as one signaling unit. TSC1 and TSC2 form a regulatory complex that acts as a GTPase-activating protein for RHEB. This helps restrain RHEB-driven mTORC1 activity.

Quick Facts

AT A GLANCE
Molecular formMulti-protein complex
Key subunitsTSC1 (hamartin), TSC2 (tuberin)

Follow the Connections

See how TSC1–TSC2 Complex links to other biological records.

Open network
ProteinTSC1 (hamartin)subunit ofProteinTSC2 (tuberin)subunit ofProteinAKT1inhibitsProteinRHEBinactivates
All 4 Structured Connections
TSC1 (hamartin) · ProteinSUBUNIT OF →TSC1–TSC2 Complex · Molecular complex
TSC2 (tuberin) · ProteinSUBUNIT OF →TSC1–TSC2 Complex · Molecular complex
AKT1 · ProteinINHIBITS →TSC1–TSC2 Complex · Molecular complex
TSC1–TSC2 Complex · Molecular complexINACTIVATES →RHEB · Protein

Recommended Reading

Trusted references for learning more about TSC1–TSC2 Complex.

pathwayMTOR signalling (R-HSA-165159)Reactome · Homo sapiens
Research Claims

TSC1 and TSC2 form a regulatory complex that acts as a GTPase-activating protein for RHEB. This helps restrain RHEB-driven mTORC1 activity.