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Receptor Tyrosine kinase signaling

Receptor tyrosine kinase signaling

How growth-factor receptors use phosphorylation to assemble signaling networks.

Overview

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Some cell-surface receptors add phosphate tags to proteins after a signal binds. These tags help pass information into the cell.

Quick Facts

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Follow the Connections

See how Receptor Tyrosine kinase signaling links to other biological records.

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ProteinEGFparticipates inProteinEGFRparticipates inProteinHER2 (ERBB2)participates inProteinHER3 (ERBB3)participates in
All 6 Structured Connections
EGF · ProteinPARTICIPATES IN →Receptor Tyrosine kinase signaling · Pathway
EGFR · ProteinPARTICIPATES IN →Receptor Tyrosine kinase signaling · Pathway
HER2 (ERBB2) · ProteinPARTICIPATES IN →Receptor Tyrosine kinase signaling · Pathway
HER3 (ERBB3) · ProteinPARTICIPATES IN →Receptor Tyrosine kinase signaling · Pathway
SHC1 · ProteinPARTICIPATES IN →Receptor Tyrosine kinase signaling · Pathway
GRB2 · ProteinPARTICIPATES IN →Receptor Tyrosine kinase signaling · Pathway

Recommended Reading

Trusted references for learning more about Receptor Tyrosine kinase signaling.

pathwaySignaling by Receptor Tyrosine Kinases (R-HSA-9006934)Reactome · Homo sapiens pathwayRAF/MAP kinase cascade (R-HSA-5673001)Reactome · Homo sapiens
Research Claims

RTK outputs are encoded by receptor context, adaptor recruitment, phosphorylation dynamics, endocytosis, and pathway feedback; individual ligands can produce distinct responses.