EGFR
epidermal growth factor receptor
EGFR is a receptor tyrosine kinase. Ligand binding can promote receptor pairing and phosphorylation, creating docking sites for adaptors that connect to RAS–RAF–MEK–ERK and PI3K–AKT signaling. Which branches dominate depends on receptor abundance, trafficking, ligand, and cell state.
Overview
EXPLORE BY LEVELEGFR is a sensor on the cell surface. When certain growth factors attach, EGFR pairs with another A protein that detects a signal, such as a hormone, and helps a cell respond. and starts messages inside the cell. Those messages can influence growth or survival, but the result depends on the cell and the signals it receives.
Quick Facts
AT A GLANCEFollow the Connections
See how EGFR links to other biological records.
All 9 Structured Connections
Recommended Reading
Trusted references for learning more about EGFR.
Research Claims
EGFR is a receptor tyrosine kinase. Ligand binding can promote receptor pairing and phosphorylation, creating docking sites for adaptors that connect to RAS–RAF–MEK–ERK and PI3K–AKT signaling. Which branches dominate depends on receptor abundance, trafficking, ligand, and cell state.