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Protein

HER2 (ERBB2)

erb-b2 receptor tyrosine kinase 2

A member of the ERBB receptor family. HER2 has no established soluble ligand of its own and can participate in signaling as a partner for other ERBB receptors.

Overview

EXPLORE BY LEVEL

HER2 (ERBB2) is a protein that helps pass or control signals inside cells. A member of the ERBB family. HER2 has no established soluble ligand of its own and can participate in signaling as a partner for other ERBB receptors.

Quick Facts

AT A GLANCE
Encoded byERBB2
Rolereceptor tyrosine kinase; mapk signaling; pi3k akt mtor

Follow the Connections

See how HER2 (ERBB2) links to other biological records.

Open network
Molecular complexEGFR–HER2 Heterodimersubunit ofGeneERBB2encodesPathwayReceptor Tyrosine kinase signalingparticipates inPathwayRAS-RAF-MEK-ERK Signaling (MAPK)participates in
All 7 Structured Connections
HER2 (ERBB2) · ProteinSUBUNIT OF →EGFR–HER2 Heterodimer · Molecular complex
ERBB2 · GeneENCODES →HER2 (ERBB2) · Protein
HER2 (ERBB2) · ProteinPARTICIPATES IN →Receptor Tyrosine kinase signaling · Pathway
HER2 (ERBB2) · ProteinPARTICIPATES IN →RAS-RAF-MEK-ERK Signaling (MAPK) · Pathway
HER2 (ERBB2) · ProteinPARTICIPATES IN →PI3K-AKT-mTOR Signaling · Pathway
EGFR · ProteinSIGNALS WITH →HER2 (ERBB2) · Protein
HER3 (ERBB3) · ProteinCAN PARTNER WITH →HER2 (ERBB2) · Protein

Recommended Reading

Trusted references for learning more about HER2 (ERBB2).

pathwaySignaling by Receptor Tyrosine Kinases (R-HSA-9006934)Reactome · Homo sapiens pathwaySignaling by ERBB2 (R-HSA-1227986)Reactome · Homo sapiens databaseERBB2 (2064)NCBI Gene
Research Claims

A member of the ERBB receptor family. HER2 has no established soluble ligand of its own and can participate in signaling as a partner for other ERBB receptors.