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Protein

RAF1 (C-RAF)

Raf-1 proto-oncogene, serine/threonine kinase

A RAF-family kinase that can relay RAS signals to MEK. RAF proteins can form dimers, so the pathway is more context-dependent than a single straight chain.

Overview

EXPLORE BY LEVEL

RAF1 (C-RAF) is a protein that helps pass or control signals inside cells. A RAF-family kinase that can relay RAS signals to MEK. RAF proteins can form dimers, so the is more context-dependent than a single straight chain.

Quick Facts

AT A GLANCE
Encoded byRAF1
Rolemapk signaling

Follow the Connections

See how RAF1 (C-RAF) links to other biological records.

Open network
GeneRAF1encodesPathwayRAS-RAF-MEK-ERK Signaling (MAPK)participates inProteinKRASactivatesProteinMEK1 (MAP2K1)phosphorylates
All 5 Structured Connections
RAF1 · GeneENCODES →RAF1 (C-RAF) · Protein
RAF1 (C-RAF) · ProteinPARTICIPATES IN →RAS-RAF-MEK-ERK Signaling (MAPK) · Pathway
KRAS · ProteinACTIVATES →RAF1 (C-RAF) · Protein
RAF1 (C-RAF) · ProteinPHOSPHORYLATES →MEK1 (MAP2K1) · Protein
RAF1 (C-RAF) · ProteinPHOSPHORYLATES →MEK2 (MAP2K2) · Protein

Recommended Reading

Trusted references for learning more about RAF1 (C-RAF).

pathwayRAF/MAP kinase cascade (R-HSA-5673001)Reactome · Homo sapiens databaseRAF1 (5894)NCBI Gene
Research Claims

A RAF-family kinase that can relay RAS signals to MEK. RAF proteins can form dimers, so the pathway is more context-dependent than a single straight chain.