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Antisense Oligonucleotides

Antisense oligonucleotides

Short synthetic nucleic-acid strands designed to bind a selected RNA sequence and alter its processing or use.

Overview

EXPLORE BY LEVEL

An antisense oligonucleotide is a short strand designed to match part of an RNA message. When it binds, it can cause the message to be broken down or change how it is read.

Quick Facts

AT A GLANCE
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Follow the Connections

See how Antisense Oligonucleotides links to other biological records.

Open network
ProcessGene Expressionhybridizes toProteinRNase H1can recruitProcessExon Skippingcan modulateProcessRNase H1-Dependent ASO Cleavagecan use
All 5 Structured Connections
Antisense Oligonucleotides · TherapyHYBRIDIZES TO →Gene Expression · Process
Antisense Oligonucleotides · TherapyCAN RECRUIT →RNase H1 · Protein
Exon Skipping · ProcessCAN MODULATE →Antisense Oligonucleotides · Therapy
Antisense Oligonucleotides · TherapyCAN USE →RNase H1-Dependent ASO Cleavage · Process
Antisense Oligonucleotides · TherapyCAN USE →Steric-Blocking ASO Mechanisms · Process

Recommended Reading

Trusted references for learning more about Antisense Oligonucleotides.

reviewMechanisms and strategies for effective delivery of antisense and siRNA oligonucleotidesPubMed Central reviewCurrent Challenges in Delivery and Cytosolic Translocation of Therapeutic RNAsPubMed Central reviewPharmacology and toxicology of eteplirsen and SRP-5051 for DMD exon 51 skipping: an updatePubMed · PMID 34797383 articleRNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machineryNucleic Acids Research · PMID 26843429
Research Claims

ASO activity depends on sequence, backbone and sugar chemistry, target accessibility, intracellular distribution, RNase H competence, and tissue exposure. Hybridization does not guarantee productive target modulation.