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326 recordsExon
A gene segment retained in a mature RNA after processing; an exon may contain coding sequence, untranslated sequence, or both.
Promoter
A DNA region near a transcription start site where RNA polymerase and associated proteins assemble to begin transcription.
TP53 · tumor protein p53
A protein-coding gene whose product helps cells respond to stress by regulating cell-cycle arrest, DNA repair, senescence, and apoptosis.
p53 · Cellular tumor antigen p53
A 393-amino-acid transcription factor that helps determine how a stressed cell responds to damage.
mTORC1 · Mechanistic target of rapamycin complex 1
A nutrient- and growth-responsive protein complex that coordinates cell growth with protein synthesis, nutrient use, and autophagy. It contains MTOR, RPTOR, and other subunits; it is not a single protein.
HBB · hemoglobin subunit beta
HBB provides instructions for beta-globin, one of the protein subunits in adult hemoglobin. Particular HBB variants produce hemoglobin S and can cause sickle cell disease when inherited in disease-associated combinations.
2-Oxoglutarate dehydrogenase complex · EC 1.2.4.2
Oxidatively decarboxylates 2-oxoglutarate to succinyl-CoA.
3-Hydroxy-3-methylglutaryl-CoA lyase · EC 4.1.3.4
Produces acetoacetate and acetyl-CoA from HMG-CoA in leucine catabolism.
3-Methylcrotonyl-CoA carboxylase · EC 6.4.1.4
Biotin-dependent enzyme in leucine catabolism.
3′ Untranslated region (3′ UTR) · 3′ untranslated region (3′ UTR)
The transcribed portion of an mRNA after its coding sequence that can influence RNA stability, location, and translation.