LEARN IN CONNECTED STEPS

Cell Biology

Explore how membranes, compartments, molecular machines, and transport let cells work as organized living systems.

FOLLOW ONE EXAMPLE

See how the pieces connect

  1. Step 1Cellworks as a living unit
  2. Step 2Membraneforms a selective boundary
  3. Step 3Transport processhelps selected molecules cross
  4. Step 4Glucoseenters through a suitable transporter
WORKED EXAMPLE

A cell membrane separates the cell from its surroundings. Some molecules cross directly; many others need a channel or carrier protein. In muscle and fat cells, GLUT4 is one carrier whose location changes in response to insulin and muscle activity.

Read the supporting reference: Molecular Biology of the Cell · Membrane structure
LOOK CLOSER

A cell is organized into working spaces

Switch between animal and plant cells to compare shared eukaryotic structures with specialized features. Membranes create different environments, while the cytoskeleton helps organize shape and movement. Bacteria and archaea have no nucleus.

INSIDE A EUKARYOTIC CELL

Compare the structures that make cells work

Open the cell record

The nucleus holds most cellular DNA. The cytoplasm includes the cytosol and structures outside the nucleus. Select a cell type, then match each numbered marker to its role. Choose an organelle name to explore its record.

CHOOSE A CELL

Compare the shared eukaryotic plan with features that distinguish plant cells.

Cell diagram
Detailed schematic of a typical animal cellA cutaway-style animal cell shows its plasma membrane, nucleus with nuclear pores and nucleolus, rough and smooth endoplasmic reticulum, Golgi stacks, mitochondrion with folded inner membrane, ribosomes, vesicles, lysosome, peroxisome, cytoskeleton, and centrosome. Numbered markers match the key below.

Typical animal cell; organelle abundance and exact arrangement vary by cell type. Both schematics are simplified, magnified, and not to scale. Markers match the structure guide below.

Plasma membrane

A thin, flexible boundary that controls exchange with the surroundings.

Cytoplasm

The region between the plasma membrane and nucleus: cytosol plus organelles and other structures.

Nucleolus

A dense region inside the nucleus where ribosomal components are assembled.

Rough endoplasmic reticulum

Membrane sheets continuous with the nuclear envelope; bound ribosomes make many secreted and membrane proteins.

Golgi apparatus

Stacks of flattened membrane sacs that modify and sort many proteins and lipids.

Mitochondrion

A double-membrane organelle; folds of its inner membrane are called cristae.

Ribosomes

Molecular machines that build proteins; some are free in the cytosol and others bind the rough ER.

Transport vesicles

Small membrane-bound carriers that move selected cargo between compartments.

Lysosome

An acidic compartment that breaks down selected material for recycling; abundance varies by cell type.

Peroxisome

A compartment for specialized oxidation reactions, including some steps in lipid metabolism.

Cytoskeleton

Protein filaments and tubes that help organize shape, movement, and intracellular transport.

Centrosome

A common animal-cell microtubule-organizing center; it is not found in every eukaryotic cell type.

BOUNDARY

Membrane

The plasma membrane separates the cell from its surroundings. Channels, carriers, and pumps help selected substances cross it.

Explore the plasma membrane →

References: OpenStax Biology 2e: Eukaryotic Cells · NCBI Bookshelf: Chloroplasts and Other Plastids · NCBI Bookshelf: Plasmodesmata.

CHECK YOUR UNDERSTANDING

What controls which molecules can cross a cell’s boundary?

Choose one answer
KEEP EXPLORING

Topics in this branch

32 linked records
01

The Cell

The smallest unit that can carry out the processes of life.

Explore this idea
02

Major Human Cell Types

Explore representative cell types across blood, immunity, organs, metabolism, the nervous system, and reproduction. This is a guided starting set, not an exhaustive inventory of every human cell state.

Explore this idea
03

Plasma Membrane

A selective boundary that separates a cell from its surroundings.

Explore this idea
04

Cytoplasm

The contents of a cell outside the nucleus, including cytosol and many cellular structures.

Explore this idea
05

Cytosol

The aqueous phase of the cytoplasm outside membrane-enclosed organelles.

Explore this idea
06

Nucleus

The membrane-bound compartment that contains most eukaryotic DNA.

Explore this idea
07

Nucleolus

A dynamic region inside the nucleus where ribosomal RNA is made and ribosome subunits begin to assemble.

Explore this idea
08

Ribosome

A ribonucleoprotein molecular machine that reads messenger RNA and assembles amino acids into a polypeptide.

Explore this idea
09

Mitochondrion

An organelle that supports energy conversion and many other cellular processes.

Explore this idea
10

Endoplasmic Reticulum

A membrane network involved in protein production and processing, lipid synthesis, and calcium storage.

Explore this idea
11

Golgi Apparatus

A membrane-bound sorting and processing center that receives cargo from the ER and sends it to destinations.

Explore this idea
12

Transport Vesicle

A small membrane-bound carrier that moves selected cargo between cellular compartments or to the cell surface.

Explore this idea
13

Lysosome

An acidic compartment where enzymes digest selected cellular material for recycling and other functions.

Explore this idea
14

Peroxisome

An organelle that carries out specialized oxidative reactions, including selected steps in lipid metabolism.

Explore this idea
15

Vesicle Transport

Membrane-bound carriers that move selected cargo between compartments or to and from the cell surface.

Explore this idea
16

Cytoskeleton

A network of protein filaments that supports cell shape, movement, organization, and intracellular transport.

Explore this idea
17

Cell Wall

A supportive outer layer found in plants, fungi, and many microorganisms; animal cells do not have cell walls.

Explore this idea
18

Membrane Transport

How molecules cross cell membranes through channels, carriers, and pumps.

Explore this idea
19

Passive Membrane transport

Movement across a membrane down a concentration or electrochemical gradient without direct energy input from ATP hydrolysis.

Explore this idea
20

Active Membrane Transport

Transport that moves substances against a gradient by coupling movement to an energy source.

Explore this idea
21

Concentration Gradients

Differences in a molecule's concentration across space that can drive diffusion and help power transport.

Explore this idea
22

Membrane Potential

A voltage difference across a cell membrane created by unequal ion distributions and selective permeability.

Explore this idea
23

Neuron

An excitable cell specialized to receive, integrate, and transmit information through electrical and chemical signaling.

Explore this idea
24

Graded Potential

A local change in membrane voltage whose size varies with the input and that can spread passively over a limited distance.

Explore this idea
25

Action Potential

A rapid, regenerative change in membrane voltage that carries signals along excitable cells such as neurons.

Explore this idea
26

Synaptic Transmission

Communication from a neuron to another cell at a specialized junction, often using neurotransmitter release and receptors.

Explore this idea
27

Voltage-Gated Ion Channel

A family of membrane-spanning protein channels whose opening or closing is influenced by membrane voltage and whose ion selectivity depends on channel structure.

Explore this idea
28

Protein Folding and Quality Control

How a protein chain adopts and maintains a functional structure, with cellular systems handling misfolded products.

Explore this idea
29

Cell Cycle

The ordered stages a cell follows as it grows and divides.

Explore this idea
30

Apoptosis Signaling

The regulated pathways cells use to initiate and execute programmed cell death.

Explore this idea
31

Endosome

A membrane-bound sorting compartment that receives endocytosed cargo and routes it for recycling, further transport, or degradation.

Explore this idea
32

Endocytosis

A family of processes that internalize extracellular material or plasma-membrane components into membrane-bound vesicles.

Explore this idea
CONNECTED RECORDS

Major Human Cell Types

64 records
Cell type

Neuron

An excitable cell specialized to receive, integrate, and transmit information through electrical and chemical signaling.

Open record
Cell type

Helper T cell

A CD4⁺ T lymphocyte that coordinates immune responses through cell contacts and secreted signals.

Open record
Cell type

B Cell

A lymphocyte whose activated descendants can secrete antibodies and form memory cells.

Open record
Cell type

Leukocyte

Leukocyte is the broad name for a white blood cell, a member of the body's immune and defense systems.

Open record
Cell type

Lymphocyte

A lymphocyte is an immune cell family that includes B cells, T cells, and natural killer cells.

Open record
Cell type

Granulocyte

Granulocytes are white blood cells with prominent cytoplasmic granules, including neutrophils, eosinophils, and basophils.

Open record
Cell type

T Cell

T cells are lymphocytes whose receptors recognize specific molecular fragments displayed by other cells.

Open record
Cell type

Epithelial Cell

Epithelial cells form sheets that cover surfaces and line many organs and tubes in the body.

Open record
Cell type

Glial Cell

Glial cells are nervous-system cells that support, protect, insulate, or regulate the environment around neurons.

Open record
Cell type

Muscle Cell

Muscle cells generate force using actin and myosin, but their structure and control differ across tissues.

Open record
Cell type

Photoreceptor Cell

Photoreceptor cells convert light into changes in electrical signaling in the retina.

Open record
Cell type

Erythrocyte

An erythrocyte, or red blood cell, carries oxygen through the blood using hemoglobin.

Open record
Cell type

Neutrophil

Neutrophils are fast-responding white blood cells that help control many bacterial and fungal infections.

Open record
Cell type

Monocyte

Monocytes circulate in blood and can take part in defense and tissue repair.

Open record
Cell type

Macrophage

Macrophages are tissue immune cells that engulf material and help coordinate defense, cleanup, and repair.

Open record
Cell type

Dendritic Cell

Dendritic cells collect and process material, then can show antigen fragments to T cells.

Open record
Cell type

Natural Killer Cell

Natural killer cells are lymphocytes that can respond to some infected or abnormal cells without first learning a unique antigen through a T-cell receptor.

Open record
Cell type

Plasma Cell

Plasma cells are antibody-secreting cells that develop from activated B cells.

Open record
Cell type

Memory B Cell

Memory B cells can persist after an immune response and respond more quickly if a related antigen appears again.

Open record
Cell type

Regulatory T Cell

Regulatory T cells help limit immune responses and support immune tolerance.

Open record
Cell type

Eosinophil

Eosinophils are granulocytes involved in responses to some parasites and in allergic inflammation.

Open record
Cell type

Basophil

Basophils are rare circulating granulocytes that can participate in allergic and type 2 immune responses.

Open record
Cell type

Mast Cell

Mast cells are tissue-resident immune cells that can rapidly release stored mediators during certain immune reactions.

Open record
Cell type

Megakaryocyte

Megakaryocytes are large bone-marrow cells that produce platelets.

Open record
Cell type

Endothelial Cell

Endothelial cells form the inner lining of blood and lymphatic vessels.

Open record
Cell type

Pericyte

Pericytes sit alongside endothelial cells on many small blood vessels.

Open record
Cell type

Fibroblast

Fibroblasts make and remodel much of the extracellular matrix that supports tissues.

Open record
Cell type

Adipocyte

Adipocytes store or use energy and send signals that help coordinate whole-body metabolism.

Open record
Cell type

Keratinocyte

Keratinocytes make up most of the epidermis and help form a protective barrier.

Open record
Cell type

Melanocyte

Melanocytes make melanin pigment and transfer pigment-containing structures to nearby cells.

Open record
Cell type

Hepatocyte

Hepatocytes are the main working cells of the liver and carry out many chemical tasks for the body.

Open record
Cell type

Cholangiocyte

Cholangiocytes line bile ducts and modify the fluid that flows through them.

Open record
Cell type

Enterocyte

Enterocytes absorb nutrients from the inside of the intestine.

Open record
Cell type

Goblet Cell

Goblet cells secrete mucus that helps protect and lubricate epithelial surfaces.

Open record
Cell type

Paneth Cell

Paneth cells release antimicrobial molecules near the base of small-intestinal crypts.

Open record
Cell type

Enteroendocrine Cell

Enteroendocrine cells sense nutrients and other cues and release hormones that help coordinate digestion and metabolism.

Open record
Cell type

Type I Alveolar Cell

Type I alveolar cells form much of the thin surface across which oxygen and carbon dioxide exchange.

Open record
Cell type

Type II Alveolar Cell

Type II alveolar cells make pulmonary surfactant, which helps keep alveoli from collapsing during breathing.

Open record
Cell type

Pancreatic Beta Cell

Pancreatic beta cells release insulin when blood glucose and other signals indicate that fuel is available.

Open record
Cell type

Pancreatic Alpha Cell

Pancreatic alpha cells release glucagon, a hormone that helps coordinate fuel availability, especially during fasting.

Open record
Cell type

Podocyte

Podocytes wrap around kidney glomerular capillaries and help form the filtration barrier.

Open record
Cell type

Proximal Tubule Epithelial Cell

Proximal tubule cells reclaim much of the filtered water and useful solutes from kidney fluid.

Open record
Cell type

Skeletal Muscle Cell

Skeletal muscle cells generate force for movement and posture and can respond to voluntary motor commands.

Open record
Cell type

Cardiac Muscle Cell

Cardiac muscle cells contract in a coordinated way to pump blood through the heart.

Open record
Cell type

Smooth Muscle Cell

Smooth muscle cells change the diameter of vessels and move or regulate material through hollow organs.

Open record
Cell type

Astrocyte

Astrocytes help maintain the chemical environment around neurons and interact with blood vessels and synapses.

Open record
Cell type

Oligodendrocyte

Oligodendrocytes make myelin around parts of axons in the central nervous system.

Open record
Cell type

Microglial Cell

Microglia are resident immune cells that monitor and respond to changes in the central nervous system.

Open record
Cell type

Ependymal Cell

Ependymal cells line fluid-filled spaces in the brain and spinal cord.

Open record
Cell type

Schwann Cell

Schwann cells support peripheral nerves and can wrap axons with myelin.

Open record
Cell type

Retinal Rod Cell

Rod cells are retinal photoreceptors that are highly sensitive to dim light.

Open record
Cell type

Retinal Cone Cell

Cone cells support color vision and detailed vision in brighter light.

Open record
Cell type

Osteoblast

Osteoblasts build new bone matrix and help control its mineralization.

Open record
Cell type

Osteocyte

Osteocytes are mature bone cells embedded in the matrix they help maintain.

Open record
Cell type

Osteoclast

Osteoclasts break down bone matrix as part of normal bone remodeling.

Open record
Cell type

Chondrocyte

Chondrocytes make and maintain the specialized matrix of cartilage.

Open record
Cell type

Sperm Cell

A sperm cell is a mature male gamete that can deliver a haploid genome to an egg during fertilization.

Open record
Cell type

Oocyte

An oocyte is a female germ cell that has entered meiosis and can contribute a haploid genome to an embryo after fertilization.

Open record
Cell type

Sertoli Cell

Sertoli cells support developing sperm cells inside the seminiferous tubules.

Open record
Cell type

Leydig Cell

Leydig cells produce testosterone in response to hormonal signals.

Open record
Cell type

Endocrine Cell

Endocrine cells release hormones or other signals that can coordinate activities in distant cells and organs.

Open record
Cell type

Connective Tissue Cell

Connective-tissue cells help make, maintain, or remodel the matrix that supports tissues.

Open record
Cell type

Blood Cell

Blood cells develop from hematopoietic stem cells and include cells that transport gases, defend against infection, or support clotting.

Open record
Cell type

Germ Cell

Germ cells give rise to gametes and pass genetic information to the next generation.

Open record